Diazotization Titration or Nitrite Titration. Diazotization is used in the analysis of aromatic compounds containing an amino group in the. View Notes – from ECH at University of Florida. Diazotization titration (Nitrite Titration) Mr. V. M. Patil Assistant Professor & PG. Quantitative estimation of Eflornithine by Nitrite (Diazotization) titration Here the amino group of Eflornithine is diazotized with sodium nitrite solution in.

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These are extremely weak and cannot be analysed using normal titrimetric methods. What is the principle involved in the diazotization titrimetry?

Another procedure is—after maintaining the conical flask temperature, the pair of platinum electrodes is immersed. What are the advantages of diazotization titrimetry?

4. Diazotization Titrations – Pharmaceutical Analysis [Book]

Selective for the all types of sulphonamides. Then the solution is slowly titrated with the 0.

Vorlander first proposed the non-aqueous titration method that is titration of aniline with the HCl in non-aqueous solvent, that is, benzene. Then the solution is titrated with the sodium nitrite solution until the starch iodide paper turns into blue colour. Share buttons are a little bit lower. The amine reacts with the nitrous acid to form nitrosamine, which is followed by the tautomerisation and the water molecule is lost to form the diazonium ion.

Sulphanilic acid and anthranilic acid. The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt. Usually 30 — 50mV of potential is applied. The diazonium salts formed are not stable at elevated temperatures. The liberated iodine is back titrated with the sodium thiosulphate using starch as the external indicator.

Maintenance of the temperature is the main condition for the diazotization titration.

A Seminar on Potentiometric and Diazotization Titrations

The reaction rate is increased by the addition of the potassium bromide solution. To use this website, titrafion must agree to our Privacy Policyincluding cookie policy. Used in the determination of the diazotizayion. Auth with social network: Volumetric or titrimetric analysis are among the most useful and accurate analytical techniques, especially. In non-aqueous titrations, usually, the milli volt scale of potentiometer is used rather than pH scale since the potential of the non-aqueous systems exceed the pH scale.

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What are the different methods used for the end point detection in the diazotization titrimetry? Relatively slow when compared to other methods. PRINCIPLE The principle involved in this method is that the primary aromatic amine present in the sample reacts with the sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt. The next method for the detection of the end point in the diazotization titration is by adding the potassium iodide to the nitrous acid with excess acid which liberates the iodine.

They are as follows: This resulting solution is known as the standard solution. This diazonium ion is stabilized by the displacement of the positive charge at the ortho titratiom para positions of the ring. The colour produced is not stable. Used in the determination of the procaine. After diazotization, one drop of the resulting solution is placed on the starch iodide paper which changes into dark colour. The diazotization titration is nothing but the conversion of the primary aromatic amine to a diazonium compound.

The excess of nitrous acid is determined by the addition of the starch iodide as an external indicator. An accurately weighed 1 mg sample of sulphonamide is dissolved in the 4 ml of concentrated HCl and in 10 ml of distilled water.

The electrode assumes a potential proportional to the logarithm of concentration ratio of the two oxidation states of the reactant or the titrant which ever is capable of titratiion poising the electrodes. The principle involved in this method is that the primary aromatic amine present in the sample reacts with tiration sodium nitrite in the presence of acid such as hydrochloric acid to obtain a diazonium salt. Used in the determination of the amphetamine.

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Used in the determination of the ephedrine. Disadvantage of fragility, imperfections in the bulb may cause error. The main principle involved in this method is to treat the amino group containing drug with the acid solution. With Safari, you learn the way you learn best.

Thus the electrode will act as if it were an electrode of metallic hydrogen. Fritz first used this method to distinguish the aromatic and aliphatic amines by using the perchloric acid as titrant. The following conditions are required for the diazotization titration of the amino group containing samples.

About project SlidePlayer Terms of Service. The principle involved in this method is that the excess nitrous acid is titeation to the titration sample solution and it is diazotiaztion titrated with the other appropriate titrant. Addition of sodium nitrite to the sample solution takes time to react with the amino group present in the sample solution. The reaction mechanism was first proposed by Peter Griessin.

Activity not concentration Concepts to review: When sodium nitrite is reacted with the hydrochloric acid sodium chloride and nitrous acid are formed. What is a chemical reaction? Another titraton for the detection of end point is by immersing the platinum electrodes in the resulting solution and it is also detected by the dead-stop end point method. Volumetric Analysis Volumetric analysis is when the volume diazotizatlon a reactant required to complete a chemical reaction is measured.

Temperature conditions to be properly maintained throughout the reaction. The general procedure is followed by weighing the sample and transferring it into the standard flask.